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Research Journal of Pharmacy and Technology
Year : 2017, Volume : 10, Issue : 7
First page : ( 2210) Last page : ( 2212)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2017.00390.0

Synthesis and Antimicrobial Evaluation of Some New Isoxazoline Incorporated Pyrrole Derivatives

Kumar Abhishek, Kumar Pankaj*, Nihana Fathima

Department of Pharmaceutical Chemistry, NGSM Institute of Pharmaceutical Sciences, Nitte University, Paneer, Deralakatte-575018, Mangalore, Karnataka.

*Corresponding Author E-mail: pankajpgr@gmail.com

Online published on 17 October, 2017.

Abstract

A series of novel substituted 3-(2, 4-dimethyl-1H-pyrrol-3-yl)-5-phenyl-4, 5-dihydroisoxazole (AFI1-AFI6) have been synthesized upon reaction with 3-(2, 4-dimethyl-1H-pyrrol-3-yl)-1-phenyl-prop-2-en-1-one using hydroxylamine hydrochloride as cyclising agent in alcohol medium. 3-(2, 4-dimethyl-1H-pyrrol-3-yl)-1-phenylprop-2-en-1-one were synthesized by condensing 3-acetyl-2, 4-dimethyl pyrrole with different substituted benzaldehyde in presence of ethanolic 20% KOH. The structures of the final synthesized compounds were characterized by IR and 1H NMR spectra. The final synthesized compounds were screened for their in vitro antibacterial activity by cup plate method.

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Keywords

Pyrrole, Isoxazoline, Antibacterial activity.

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