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Research Journal of Pharmacy and Technology
Year : 2017, Volume : 10, Issue : 7
First page : ( 2139) Last page : ( 2142)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2017.00376.6

In Vivo studies of Ophthalmic Ocular Insert Containing Aciclovir

Valarmathi S.1,*, Shanmugam S.2, Kumar S. Satheesh3, Shanmugasundaram P.3

1Research Scholar, School of Pharmacy, Vels University, (VISTAS), Pallavaram, Chennai, Tamil Nadu

2Adhiparasakthi College of Pharmacy, Melmaruvathur, Tamil Nadu

3School of Pharmacy, Vels University, (VISTAS), Pallavaram, Chennai, Tamil Nadu

*Corresponding Author E-mail: sahanashree2012@gmail.com

Online published on 17 October, 2017.

Abstract

Aciclovir is an antiviral drug used to treat viral infections like herpes simplex virus. The aim of the present research work was to develop ocular inserts of aciclovir and evaluate their drug release for both in vitro and in vivo. The draw backs of other ophthalmic formulations (solutions, suspensions, ointment) like poor bioavailability, patient non compliance, quick drug elimination was overcome by formulating the drug in ocusert formulation.1, 2 The ocuserts was prepared by solvent casting technique using hydrophilic and hydrophobic polymers. Eight formulations was prepared with formulation code of F1, F2, F3, F4, F5, F6, F7, F8. The satisfied drug release was achieved in F2 formulation. The selected formulation F2 was subjected to sterilization before performing in vivo studies.3, 46 healthy rabbits are used for in vivo study. Draize irritation studies are carried out to check the compatibility of ocusert in the eyes. After 21 days of irritation study the eyes are examined. Drug content of the ocuserts are calculated at predetermined time intervals and subtracted from the initial value.5Theinvivo drug release results are correlating with invitro drug release, which shows better therapeutic efficacy.

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Keywords

Aciclovir, in vivo, Draize irritation, Rabbits, drug content.

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