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Research Journal of Pharmacy and Technology
Year : 2017, Volume : 10, Issue : 7
First page : ( 2132) Last page : ( 2135)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2017.00374.2

Assessment of Procollagen 111N Terminal Peptide Level in Rats Undergo CCl4 and Bile Duct Ligation

Arif Rusul, Jaffat Haider Salih*

Faculty of Science, University of Kufa

*Corresponding author e-mail: haider_salih1968@yahoo.com

Online published on 17 October, 2017.

Abstract

This study was conducted at the laboratory of department of biology, faculty of science/university of Kufa during the period extended from 7, September, 2016 to 5, February, 2017, 45 male rats that was used which is divided in to three groups, Group 1: male rats administered with drinking water as negative control (N. C.). Group 2: male rats administered with CCL4 for one month, Group 3: male rats undergo Bile duct ligation for one week,. At the end of treatment period, which has been extended for five weeks, male rats have been sacrificed and blood samples obtained for assessment of (P111NP and levels of WBC, Hb and PCV). The result have a significant elevate (p< 0.05) in level of P111NP and WBC in rats undergo BDL and CCL4 treatment compare to control groups.a significant decrease (p< 0.05) in level of Hb and PCV in rats undergo BDL and CCL4 treatment compare to control groups.

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Keywords

Bile duct ligation, Procollagen111 N terminal peptide.

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