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Research Journal of Pharmacy and Technology
Year : 2017, Volume : 10, Issue : 6
First page : ( 1816) Last page : ( 1819)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2017.00320.1

Transethosome: Novel vesicular carrier for enhanced transdermal drug delivery system

Jondhalekar T. M.1,*, Aher S. S.2, Saudagar R. B.2

1Department of Quality Assurance, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, India.

2Department of Pharmaceutical Chemistry, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, India.

*Corresponding Author E-mail: tejal.jondhalekar@gmail.com

Online published on 22 September, 2017.

Abstract

Transethosomes are noninvasive delivery carriers that enable drugs to reach the deep skin layers and the systemic circulation. Although transethosome systems are conceptually sophisticated, they are simple in their preparation, safe for use a combination that can highly expand their application. Transethosome are gaining popularity in designing drug delivery systems for topical and transdermal use for their capability to reach deep skin layers and systemic circulation. The dermal route has been recognized as one of the highly potential routes of systemic drug delivery and provide the advantage of avoidance of the first pass effect, ease of use and withdrawal (in case of side effects) and better patient compliance. Transethosome have both ethanol and penetration enhancer due to which drug penetrates through stratum corneum by increase fluidity of cell membrane lipids. The present review includesthe composition, mechanism of penetration, advantage, method of preparation and characterization of transethosome.

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Keywords

Transethosome, Transdermal Drug Delivery, Stratum corneum, Permeation enhancers.

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