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Research Journal of Pharmacy and Technology
Year : 2017, Volume : 10, Issue : 6
First page : ( 1679) Last page : ( 1682)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2017.00296.7

Synthesis and in-vitro anti-inflammatory activity of novel pyrazoline derivatives

Fernandes Jennifer*, Revanasiddappa B. C., Ishwarbhat K., Kumar M. Vijay, D'Souza Lidwin, Smitha Alva Shanal

Department of Pharmaceutical Chemistry, NGSM Institute of Pharmaceutical, Sciences of Nitte University, Paneer, Deralakatte, Mangalore-575 018, Karnataka, India

*Corresponding Author E-mail: jennifer_pharma@yahoo.co.in

Online published on 22 September, 2017.


A new series of Chalcones (2a-j) were prepared by reacting 2-acetyl Pyrrole and substituted ketones in alcohol medium in presence of NaOH. The Chalcones undergoes selective cyclization with phenoxy acetic acid hydrazide (1) in glacial acetic acid medium to yield the title compounds 1,3,5-trisubstituted Pyrazolines (3a-j). The newly synthesized compounds were evaluated for their In-vitro anti-inflammatory activity by egg albumin denaturation and protein denaturation method. All the new compounds were established on the basis of 1H-NMR, IR and Mass spectral data. Some of the tested compounds 3a, 3f showed good anti-inflammatory activity when compared to the standard drug diclofenac sodium.



Oxazolones, Imidazolinones, N-acetylglycine, Antibacterial, Antifungal.


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