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Research Journal of Pharmacy and Technology
Year : 2017, Volume : 10, Issue : 6
First page : ( 1675) Last page : ( 1678)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2017.00295.5

Assessment of cyclophilin-A level in women with heart disease after menopause

Al-Kraity Wijdan Rajh Hamza*, Al-Dujaili Arshad Noori Ghani

Biology Department, Faculty of Sciences, University of Kufa, Iraq.

*Corresponding Author E-mail: Wijdanrh.sc12p@uokufa.edu.iq

Online published on 22 September, 2017.

Abstract

In the current study, Seventy menopausal women have CHD were admitted to the coronary care unit of AL-Sader teaching hospital in AL-najaf AL-Ashraf during the period from January to April/2016 for the ages were ranging from 40 to 69 years old. The samples were divided into three groups (SA 25, UA 22, AMI 23), while the healthy group was composed of 20. The current study indicated a significant increase(p<0.05) in serum CYP-A of CHD compared with healthy group, while a significant decrease (P<0.05)in serum E2 concentration of CHD compared with healthy group. The results also revealed a significant increase(p>0.05)of serum CYP-A concentration in AMI group as compare with UA group and SA group of CHD, While serum of E2 concentration showed a significantly decrease (p<0.05)in AMI compare with UA and SA groups of CHD. The result showed also a negative correlation between E2 and CYP-A. The present study concluded that E2 and CYP-A were markers for detection and diagnosis of Coronary heart disease in menopausal women.

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Keywords

Coronary heart disease, Menopause, Estradiol and Cyclophilin-A.

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