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Research Journal of Pharmacy and Technology
Year : 2017, Volume : 10, Issue : 6
First page : ( 1647) Last page : ( 1652)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2017.00290.6

Hepatoprotective activity of the hydro-alcoholic extract of the Gracilaria edulis (Gmelin)

Sikdar Pranabesh1, Ramana M. Venkata2

1Department of Pharmaceutical Chemistry, Seven Hills College of Pharmacy, Ramachandra Puram Mandal, Tirupati-517561, Andhra Pradesh, India.

2Gurram Balanarasaiah Institute of Pharmacy, Edulabad (V), Ghatkesar (M), Ranga Reddy-501 301, Andhra Pradesh, India

Online published on 22 September, 2017.

Abstract

In recent years seaweeds have increasingly attracted interest in the search for new drugs and have been shown to be a primary source of bioactive natural compounds and biomaterials. In the present investigation, the biochemical composition of the red seaweed Gracilaria edulis, collected seasonally in the tuticorin (South India), was assayed by means of advanced analytical techniques, in the present study the hydro-alcoholic extract of the Edulis was taken for Hepatoprotective activity using paracetamol model. The Phenolic content of the extract was also determined and it can be expressed as gallic acid equivalent i.e 49.33±1.23 mg/g of the extract. The extract have found to show significant decrease in the level of biomarker release at 300mg/kg and 400mg/kg. But the bodyweight have not shown the significant increase.

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Keywords

Hepatoprotective activity, G. edulis, Phenolic content.

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