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Research Journal of Pharmacy and Technology
Year : 2017, Volume : 10, Issue : 5
First page : ( 1502) Last page : ( 1508)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2017.00265.7

A Review on Extrusion-Spheronisation

Boddeda Bhavani1,*, Bandaru Pratyusha2, Rao Y. Srinivasa2

1Associate Professor, Vignan Institute of Pharmaceutical Technology, Visakhapatnam

2Vignan Institute of Pharmaceutical Technology, Visakhapatnam, India

*Corresponding Author E-mail: bhavani2008@gmail.com

Online published on 17 July, 2017.

Abstract

Pellets, being multiple unit-dosage forms, are widely used as they offer both manufacturing and therapeutic advantages over single-unit solid dosage forms. There are various techniques to manufacture pellets. Extrusion/Spheronisation or maramuerization is a rapid, flexible and a multi-step process capable of making uniformly sized spherical particles commonly referred to as spheres or pellets of diameter ranging from about 0.5mm to 10mm. It is a best method as it has an advantage of excellent product flowability, easy scale-up, high yield, narrow particle size distribution, excellent process repeatability. Various techniques used to produce pellets, steps involved, equipments used, effect of process variables involved in extrusion spheronisation process, evaluation parameters and properties requirement of final pellets produced are covered in review. We highlighted the effect of process variables on final quality of pellet.

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Keywords

Various techniques, Spheronisation steps, Process variables, Evaluation.

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