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Research Journal of Pharmacy and Technology
Year : 2017, Volume : 10, Issue : 5
First page : ( 1402) Last page : ( 1416)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2017.00250.5

Development and Screening of Anticonvulsant Polyherbal Formulation

Mahanthesh M.C.1,4,*, Gautam Girendra2, Jalalpure S.S.3

1Bhagwant University, Ajmer

4Tatyasaheb Kore College of Pharmacy, Warananagar-416113, Maharashtra, India

2Department of Pharmacy, Bhagwant University, Ajmer, Rajasthan, India

3Department of Pharmacognosy, KLE'S College of Pharmacy and Dr. Prabhakar Kore Basic Science Research Centre, KLE University, Belgaum-10, Karnataka, India

*Corresponding Author E-mail: mc_mahanthesh@rediffmail.com

Online published on 17 July, 2017.

Abstract

Objective

To explore the pharmacognostical characteristics and in vivo anticonvulsant activity of chloroform extracts of Diplocyclos palmatue leaves, Abutilon indicum Linn sweet stem and Cassia occidentalis whole plant formulation.

Methods

The plants were successively extracted using chloroform. The extract was screened for phytochemicals using HPTLC, GCMS techniques. The extract was also screened for acute toxicity and herbal formulation anticonvulsant activity, against MES and PTZ induced convulsions, using Wistar albino rats.

Results

The phytochemical screening study reveals the presence of more chemical constituents in chloroform extract. We found no significant changes in average body weight of animals, up to tested oral dose of 3000 mg/kg, during acute toxicity study and suspension having good stability on storage. The in vivo study reveals the anticonvulsant activity of chloroform extract against MES and PTZ induced convulsions. The chloroform extract is found to be more potent, similar to Phenytoin, in controlling both MES and PTZ induced convulsions.

Conclusions

The results obtained suggest that the formulation has remarkable anticonvulsant activity. Also, our study indicates the potential application of these combined herbal dosage forms could be suitable for anticonvulsant activity. However, this claim demands through investigation in other models for anticonvulsant activity.

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Keywords

Shivling, Atibala, Neegro coffee, anticonvulsant, HPTLC and GCMS.

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