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Research Journal of Pharmacy and Technology
Year : 2017, Volume : 10, Issue : 5
First page : ( 1344) Last page : ( 1346)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2017.00238.4

Synthesis and Biological Evaluation of Some Novel Pyrazoline Derivatives Derived from Chalcones

Bhat K. Ishwar, Kumar Abhishek*

Department of Pharmaceutical Chemistry, NGSM Institute of Pharmaceutical Sciences, Nitte University, Paneer, Deralakatte-575018, Mangalore, Karnataka

*Corresponding Author E-mail: abhi12bunty@gmail.com

Online published on 17 July, 2017.

Abstract

A novel series pyrazoline derivatives have been developed as chemotherapeutic agents and have found wide clinical applications such as antibacterial, anticancer, antifungal and antitubercular agents. Chalcones are known to exhibit interesting pharmacological activities like anti-inflammatory, antileishmanial, antibacterial, antitumor, antimalarial and antitubercular activity. A series of pyrazoline derivatives [Substituted 1, 5-diphenyl-3-(m-tolyl)4, 5-dihydro-1H-pyrazole] were prepared from chalcones by the reported method, characterized by IR, 1H NMR and mass spectra. The synthesized compounds were evaluated for antitubercular and cytotoxic activity studies. Most of the compounds have exhibited promising antitubercular and cytotoxic activities.

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Keywords

Chalcones, Pyrazolines, Antitubercular activity, Cytotoxic activity.

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