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Research Journal of Pharmacy and Technology
Year : 2017, Volume : 10, Issue : 5
First page : ( 1313) Last page : ( 1316)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2017.00232.3

Hepatoprotective activity of methanolic extract of Terminalia coriacea leaves

Patel Jitendra1,*, Reddy A. Venkateshwar2, Kumar G.S.3, Satyasai D.4, Bajari B.4, Nagarjuna V.4

1Jawaharlal Nehru Technological University, Kukatpally-500070, Hyderabad, Telangana, India

2Anwarul Uloom College of Pharmacy, New Mallepally, Hyderabad-500001, TS, India

3Department of Life Sciences, School of Pharmacy, IMU, Bukit Jallil, Kuala Lumpur-57000. Malaysia

4KVK College of Pharmacy, Surmaiguda (V), Hayathnagar (M), RR Dist.-501512, TS, India

*Corresponding Author E-mail: jittupharmacy@gmail.com

Online published on 17 July, 2017.

Abstract

The present study was aimed to investigate hepatoprotective activity of methanol extract of the leaves of Terminalia coriacea. Group I served as vehicle control, Group II served CCL4 (2ml/kg, S.C.), Group III served as standard Silymarin (50 mg/kg, p.o.) Group IV and V served as methanolic extracts of Terminalia coriacea (METC) at the dose level (250 and 500 mg/kg, p.o.). The degree of protection was determined by measuring level biochemical marker like alanine aminotransferase (ALT), aspartate aminotransferase(AST), alkaline phosphatase (ALP), direct bilirubin, total bilirubin and Cholesterol. The histopathology study also showed the hepatic protection of extracts. The marker biochemical level such as ALT, AST, ALP, Direct bilirubin, Total bilirubin and Cholesterol were significantly raised in CCL4 treated rats when compared with the normal group (p<0.05), but the METC (500 mg/kg, bw) treated rats exhibited maximum depletion. The histopathology study also showed the hepatic protection of extracts. The results of in vivo hepatoprotective activity showed that the methanol extract of Terminalia coriacea exhibit significant hepatoprotective activity.

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Keywords

Terminalia coriacea (Roxb.) Wight and Arn leaves, Methanolic extract, CCL4, Hepatoprotective and Silymarin.

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