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Research Journal of Pharmacy and Technology
Year : 2017, Volume : 10, Issue : 4
First page : ( 1215) Last page : ( 1224)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2017.00218.9

Review on: New approaches in self micro-emulsifying drug delivery system

Misal Ravindranath S.*, Potphode Vishawas R., Mahajan Vijay R.

Department of Pharmaceutics, SMBT College of Pharmacy, Nandi Hills Dhamangaon, Tal. Igatpuri, Dist. Nashik-422403

*Corresponding Author E-mail: misalravindranath@gmail.com

Online published on 17 July, 2017.

Abstract

Self Micro-Emulsifying drug delivery system is recent and novel approaches have been attracted to considerable interest as an efficient means for improving solubility, dissolution rate and oral bioavailability of API (Active Pharmaceutical Ingredient). Now a day's up to 40% of new drug chemical entities developed and discovered by pharmaceutical industry by recent years such as poorly soluble and highly permeable lipid based drug delivery system (such as lipophilic compound). SMEDDS are most important approaches for improvement of solubility enhancement of lipid based BCS Class II drug delivery system. SMEDDS is isotropic mixture of oil, hydrophilic surfactant and co-surfactant and solubilised drug. This formulation spontaneously from fine oil-in-water microemulsion upon dilution with water. They can be encapsulated in hard or soft gelatin capsule or to form other solid dosage forms by using various recently developed techniques such as spry drying, adsorption to solid carrier, melt granulation, melt extrusion/extrusion speronization and encapsulation in liquid and semisolid dosage forms. Oral delivery of such drugs is complicated for the reason that of their low bioavailability, high intra and inter-subject variability and not have dose linearity. The article gives complete overview of SMEDDS but special attention has been shown to formulation, design, evaluation and application of SMEDDS.

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Keywords

Oral bioavailability, dissolution rate, Self Micro-Emulsifying drug delivery system, solubility, permeability and BCS Class-II drug.

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