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Research Journal of Pharmacy and Technology
Year : 2017, Volume : 10, Issue : 4
First page : ( 1179) Last page : ( 1183)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2017.00225.6

Simultaneous determination of Ketorolac tromethamine and Fluorometholone in Eye drops by spectrophotometry

Annapurna Mukthinuthalapati Mathrusri*, Sevyatha Vellanki S. V., Sushmitha Malineni

Department of Pharmaceutical Analysis and Quality Assurance, GITAM Institute of Pharmacy, GITAM University, Visakhapatnam-530045, India

*Corresponding Author E-mail: mathrusri2000@yahoo.com

Online published on 17 July, 2017.

Abstract

Four simple spectrophotometric methods have been developed for the simultaneous determination of Fluorometholone and Ketorolac tromethamine in ophthalmic preparations. Simultaneous equation method, absorbance ratio method (Q-Analysis), first derivative method and multicomponent mode of analytical techniques were selected for the determination of Fluorometholone and Ketorolac tromethamine in phosphate buffer (pH 2.0) solution. Fluorometholone and Ketorolac tromethamine has followed linearity over the concentration range 0.1–20 μg/mL and 1–20 μg/mL respectively. The methods were validated and applied for the simultaneous determination of Fluorometholone and Ketorolac tromethamine in the available pharmaceutical formulations i.e. eye drops.

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Keywords

Fluorometholone, Ketorolac tromethamine, Spectrophotometry, Simultaneous equation method, Simultaneous derivative, Multicomponent analysis, Q-Analysis, Validation.

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