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Research Journal of Pharmacy and Technology
Year : 2017, Volume : 10, Issue : 4
First page : ( 1049) Last page : ( 1052)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2017.00190.1

Synthesis, Biological and Pharmacological Screening of Novel Pyrimidine Derivatives

Bhat K. Ishwar1, Kumar Abhishek2,*

1Department of Pharmaceutical Chemistry, NGSM Institute of Pharmaceutical Sciences, Nitte University, Paneer, Deralakatte-575018, Mangalore, Karnataka

2Assistant Professor, Department of Pharmaceutical Chemistry, NGSM Institute of Pharmaceutical Sciences Paneer, Deralakatte, Mangalore-575018, Karnataka, India

*Corresponding Author E-mail: abhi12bunty@gmail.com

Online published on 17 July, 2017.

Abstract

A series of novel 4-(4-nitrophenyl)-6-phenyl substituted pyrimidine-2-thiol (PM1-PM6) have been synthesized by refluxing 1-(4-nitrophenyl)-3-phenyl substituted prop-2-en-1-one in presence of thiourea and glacial acetic acid. 1-(4-nitrophenyl)-3-phenyl substituted prop-2-en-1-one were prepared by condensing 4-nitroacetophenone with substituted benzaldehydes in presence of 20% NaOH as base. The structures of newly synthesized compounds were characterized by IR, 1H NMR and mass spectroscopic studies. Newly synthesized compounds were screened for their anti-inflammatory and cytotoxic studies. Few of the compounds exhibited excellent anti-inflammatory compared to the standard drug diclofenac sodium. Some compounds have shown moderate cytotoxic activities.

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Keywords

Chalcones, pyrimidine, cytotoxic activity, anti-inflammatory activity.

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