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Research Journal of Pharmacy and Technology
Year : 2017, Volume : 10, Issue : 4
First page : ( 1025) Last page : ( 1028)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2017.00185.8

Formulation and Evaluation of Quick Dissolving Films of Promethazine Hydrochloride

Birla Nikhlesh, Mandloi Kavita, Mandloi Rampal*, Dr. Pillai Sujit

GRY Institute of Pharmacy, Vidhya Vihar Borawan-451228, Khargone (M.P)

*Corresponding Author E-mail: rampalmandloi@gmail.com

Online published on 17 July, 2017.

Abstract

Fast dissolving dosage forms have acquired great importance in pharmaceutical industry because of their unique properties like dissolve upon contact with a wet surface, such as the tongue, within a few seconds, meaning the consumer can take the product without need for additional liquid. This convenience provides both a marketing advantage and patient compliance. The present study aimed at preparing fast dissolving oral films of Promethazine Hydrochloride oral fast dissolving films that offers a suitable approach for the treatment and management of nausea and vomiting. In the present investigation different types of polymer like HPMC, HPC, polyvinyl pyrolidone, aspartame, poly vinyl alcohol to prepare quick films. The prepared films were evaluated for film thickness, folding endurance, surface pH, morphological properties, % drug content and content uniformity, tensile strength, percent elongation, in vitro disintegration time and in vitro dissolution studies.

The physical appearance was found to be good and shows that films were transparent physical appearance was found to be good and shows that films were transparent with smooth surface without any scratches. The folding endurance was showed that films have good flexibility. In-vitro drug release for Promethazine of all the formulations showed 60–90% within four minutes.

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Keywords

Quick dissolving films, Promethazine Hydrochloride, Solvent casting, Poly vinyl alcohol, Poly vinyl pyrolidone, HPMC, HPC, Aspartame.

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