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Research Journal of Pharmacy and Technology
Year : 2017, Volume : 10, Issue : 4
First page : ( 1015) Last page : ( 1019)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2017.00183.4

Analytical Method Development and Validation of Anostrozole in Pure and Tablet Dosage Form by UV Spectroscopy

Sreejith K.R.*, Rajagopal P.L., Premaletha K.

Academy of Pharmaceutical Sciences, Pariyaram Medical College, Kannur, Kerala

*Corresponding Author E-mail: krsreejith5228@gmail.com

Online published on 17 July, 2017.

Abstract

The present study deals with development and validation of a simple, rapid, accurate, economical and reproducible UV-Spectrophotometric method for estimation of Anostrozole in pure form and in tablet dosage form. Area under the curve in the range of 220-231nm of the absorption spectrum was selected for the analysis. Linearity range was found to be 4–20 μg/ml. The correlation coefficient was found to be 0.9997. The molar absorptivity was found to be 37430 L mol/cm. The limit of detection and limit of quantification were found to be 0.3560and 1.0789 μg/ml respectively. The assay value of Anostrozole in bulk and formulation was calculated at different time intervals for intraday and interday experiments. The proposed method was successfully applied for the determination of Anostrozole in bulk form and in Pharmaceutical formulation.

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Keywords

Anostrozole, UV-Spectroscopy, Validation, ICH guidelines, Area under the curve.

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