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Research Journal of Pharmacy and Technology
Year : 2017, Volume : 10, Issue : 3
First page : ( 785) Last page : ( 788)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2017.00147.0

Standardization of Extrusion Parameters during Liposomal Oxaliplatin Creation

Stadnichenko A.V.2,*, Krasnopolsky Y.M.1, Yarnykh T.G.2

1National Technical University Kharkiv Polytechnic Institute, Ukraine, 61000, Kharkov, Kirpichova St. 21

2National University of Pharmacy, Ukraine, 61002, Kharkov, Pushkinskaya St. 53

*Corresponding Author E-mail: alstn@mail.ru

Online published on 29 April, 2017.

Abstract

The articl is dedicated to development of anticancer drug oxaliplatin in liposomal form. The drug is prospective from point of view of use in clinical practice as a form of low-toxic cytostatic drug for anticancer therapy. The principles for development of the lipid particles and impotence of their size for the formulation with high level of encapsulation is discussed. Parameters of high pressure homogenization techniques were researched. Method was standardized in field of the process parameters. Finished product was characterized by following parameters: size of the liposomes, encapsulation degree and zeta potential.

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Keywords

Oxaliplatin liposomes, phosphatidylcholine, alipid bilayer, homogenisation, extrusion under high pressure.

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