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Research Journal of Pharmacy and Technology
Year : 2017, Volume : 10, Issue : 3
First page : ( 677) Last page : ( 682)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2017.00126.3

Synthesis and Characterization of Indolyl-pyrazoline and their Evaluation of anti-inflammatory Activity

M Shroff inakshi1,*, Dr. Daharwal S. J.2, Swarnakar Yashwant3

1Deptt. of Pharmaceutical Sciences, Uttarakhand Technical University, Deheradun, U.K.

2University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur, C.G.

3Shri Shankaracharya Institute of Pharmaceutical Sciences, Bhilai, C.G.

*Corresponding Author E-mail: mahishroff@gmail.com

Online published on 29 April, 2017.

Abstract

In the present work, ten novel 3-(4, 5-dihydro-3-(naphthalen-1-yl)-N1-substituted-pyrazol-5-yl)-1H-indole [1, 1a, 1b.1e, 2] and 3-(4, 5-dihydro-3-(pyridin-3-yl)-N1-substituted-pyrazol-5-yl)-1H-indole [5, 5a, 5b, 5e.6] were synthesized by condensation between substituted pyrazoline and substituted hydrazine in the presence of glacial acetic acid. The synthesized compounds were evaluated for their anti-inflammatory activity using carrageenaninduced paw oedema method and compared to the well known NSAID indomethacin as a standard drug. The entire synthesized compounds were characterized by elemental analysis, IR, 1H NMR and mass spectroscopy.

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Keywords

Anti-inflammatory activity, Carageenan induced paw oedema method, indole, pyrazoline, indolyl pyrazoline.

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