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Research Journal of Pharmacy and Technology
Year : 2017, Volume : 10, Issue : 3
First page : ( 647) Last page : ( 662)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2017.00123.8

Scrutiny of Antagonistic Microbial and Cytotoxic Promises of Fungal Endophyte Secluded from Pisonia grandis R. Br.

Sasikumar C.1,*, Mohana S. J.2, Yasodha S.3

1Asst. Professor, Jeppiaar Institute of Technology, Sriperumbudur, India

2PhD Research Scholar, Gurunank College, Chennai, India

3Research Scientist, Royal Bio Research Center, Chennai, India

*Corresponding Author E-mail: sasikumarc@jeppiaarinstitute.org

Online published on 29 April, 2017.

Abstract

In the past decades, hundreds of bioactive natural products had been isolated from endophytic fungi among which over 51% were chemically novel. But to this day, only a small population of the endophytic fungi have been investigated for the bioactivity assessment and production of natural compounds. So the possibility to find bioactive endophytic fungal strains and bioactive natural products with chemically novel structures from them is still high. In the present study we aim to isolate and identify fungal endophytes from Pisonia grandis R. Br. and to analyse their Antimicrobial, Antioxidant and Anticancer potential. One out of the four different endophytic fungi obtained was selected for studies on bioactivity and was identified as Neurospora crassa. On evaluating the bioactivities, the fungus exhibited moderate to good Antimicrobial activity against the Assessment organisms and more than 50% antioxidant activity. The data obtained from Cytotoxicity studies revealed a dose-dependent cytotoxic activity. The compounds present in the extract were identified through GC-MS analysis.

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Keywords

Pisonia grandis R. Br, Endophytic fungi, Neurospora crassa, Bioactivity assay, GC-MS.

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