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Research Journal of Pharmacy and Technology
Year : 2017, Volume : 10, Issue : 11
First page : ( 4005) Last page : ( 4010)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2017.00726.0

Biological and Phytochemical Studies on the leaves of Caesalpinia decapetala (Roth)

Sharma V1, Wadhwa S1, Lobo R2, Gupta P1, Amini M.H3, Kaur J4, Suttee A1,*

1Pharmacognosy and Phytochemistry Dept. of School of Pharmaceutical Sciences, Lovely Professional University, Punjab, India

2Manipal College of Pharmaceutical Sciences, Manipal University, Manipal

3Department of Pharmacognosy, Kabul University, Afghanistan

4ACPTE, Sangrur, Punjab

*Corresponding Author E-mail: ashish7sattee@gmail.com

Online published on 26 March, 2018.

Abstract

The present correspondence endeavours to assess the biological and phytochemical studies about on the leaves of Caesalpinia decapetala (Roth) fabaceae family collected from forest area of Tamilnadu, India.

Methods

The crude drug was successively extracted by Soxhlet assembly using Petroleum ether, dichloromethane, ethyl acetate and methanol as solvents. Preliminary phytochemical screening of different extracts was carried out using several color and precipitative chemical reagents as per described methods.. Antioxidant activity of the extracts was evaluated using DPPH as standard Apart from DPPH method, ferric reduction method and H2O2 scavenging method assay were also used for evaluating its antioxidant activity.

Results

Preliminary phytochemical screening of C. decepetala leaves showed the presence of alkaloids, glycosides, phenols, phytosterols, saponins and flavonoids crude drug. C. decapetala leaf extracts exhibited marked dose dependent antibacterial activity in vitro against tested bacteria. It has also shown potent antioxidant activity.

Conclusion

Various phytochemicals were found to be present in C. decepetala leaves. Methanolic extract of C. decapetala leaves exhibited better antioxidant in vitro and can be used as a good therapeutic approach for disease management and therapy. Further studies on isolation of phyto-constituents and both in vitro and in vivo evaluation of pharmacological activities of isolated bioactive constituents of the crude drug are recommended as future works.

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Keywords

C. decapatala, Fabaceae, phytochemical screening, acute toxicity, antioxidant activity.

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