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Research Journal of Pharmacy and Technology
Year : 2017, Volume : 10, Issue : 11
First page : ( 3877) Last page : ( 3880)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2017.00704.1

Docking of HIV-1 with Neem using Autodock in Bioinformatics

Kannadasan R.1,*, Emerson I. Arnold2, Basha M. S. Saleem3

1School of Computer Science and Engineering, VIT University, Vellore-632014, India

2School of Bioscience and Technology, VIT University, Vellore-632014, India

3Department of Computer Science, Mazoon University College, Muscat, Sultanate of Oman

*Corresponding Author E-mail: desurkannadasanr@gmail.com

Online published on 26 March, 2018.

Abstract

Protein is a chain amino acid each connected to its neighbor through a covalent peptide bond, therefore proteins are also known as polypeptides. HIV-1 disease is intellectual weakness which can go in seriousness from a mellow subclinical subjective wastefulness to an extreme twisting ailment. Human Immunodeficiency Virus (HIV) taints the cells of the insusceptible framework. Specifically, HIV assaults and pulverizes the T partner lymphocytes, or T-cells, which are essential to the insusceptible framework and invulnerable reaction. Docking enables us to understand the molecular interaction which take place between a ligand and a contrasting protein. The molecular docking can be done by an open source program which is the Auto Dock, It is developed to mimic and foresee how a drug and a ligand of known structure bind. This is used to find the binding energy and the inhibition constant. This information can be used to synthesize drugs for HIV-1.

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Keywords

HIV-1, Neem, Auto dock.

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