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Research Journal of Pharmacy and Technology
Year : 2017, Volume : 10, Issue : 11
First page : ( 3757) Last page : ( 3760)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2017.00682.5

Binding Efficiency of Molecules from Medicinal Plants with Fidgetin Like Protein 2-A Novel Target for Diabetic Foot Ulcer

Kumar R. Sathish1,*, Kaavya G.2

1Assistant Professor, Department of Botany, PSG College of Arts and Science, Coimbatore

2Department of Biochemistry, PSG College of Arts and Science, Coimbatore

*Corresponding Author E-mail: sathishbioinf@gmail.com

Online published on 26 March, 2018.

Abstract

Diabetic foot ulcer (DFU) is one of the major complications for diabetes patients. DFU interrupts the normal steps involved in wound healing process and upto25% of diabetes patients develops DFU in India. At present situation, the treatment for DFU is mandatory. Perhaps bioactive compounds from medicinal plants might have an impact, therefore plants like Aloe vera, Coptis chinensis, Equisetum arvense, Paeonia suffruticosa, Rehmannia glutinusa and Rheum palmatum has been screened for its binding efficiency with fidgetin like protein 2 (FLP2). Out of several compounds studies, α-D-glucopyranoside showed the least G.score value 7.91Kcal/mol. The compound is present in the plant Equisetum arvense, in future could be analyzed for treating DFU. The binding efficiency was studies using docking software, where the 3D of the protein was modeled using the online tool I-tasser. The protein sequence was retrieved from the UniProt database of ID: A6NMB9 and the quality of the modeled structure were determined from the Ramachandran plot generated from the SAVS (online server). In the present study the compound α-D-glucopyranoside (Equisetum arvense) had effective binding with the protein and least G.score value. Therefore further studies can be done in isolating the bioactive compounds from Equisetum arvense could be carried out.

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Keywords

Fidgetin like protein 2, Molecular modeling, I-Tasser, Docking analysis, Equisetum arvense, α-D-glucopyranoside.

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