Synthesis, characterization and study of biological activity of some new 1, 2, 3, 4-Tetrazole derivatives.
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This study aimed to prepare some new 1, 2, 3, 4-Tetrazole derivatives from o-tolidine as a starting materials and to detection antibacterial activity against two type of pathogenic bacteria (Staphylococcus aureus and Klebsiella pneumoniae) isolated from patients infected with burns infections: The first step includes formation of new Schiff bases derivatives from o-tolidine [A] concentrated with many aromatic aldehydes [4-chlrobenzaldehyde, 4-bromobenzaldehyde, p-dimethyle amino benzaldehyde] in absolute ethanol to give [A1-A3]. The second step includes synthesis [B1-B3] by diazotation of [1-(4-aminophenyl) ethanone, 4-amino-N-(2H-imidazol-2-yl) benzenesulfon amide, 4-nitroaniline], respectively. The formed salt was treated with sodium azide, ethyl acetoacetate and acetylacetone, respectively. [B1-B3] Compounds were entered in 1, 3-dipolar cycloaddition reactions with [A1-A3] in dimethylformamide to give 1, 2, 3, 4-Tetrazole derivatives [AB1-AB3]. Antibacterial activity of nine derivative compounds were done against two types of pathogenic bacteria (p. aeruginosa and S. aureus). Results of this study proved that there were significant bacterial inhibition against p. aeruginosa and S. aureus with inhibition zone 20 mm and 15 mm, respectively.
O-tolidine, Schiff bases, 1, 2, 3, 4-Tetrazole, Iraq.