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Research Journal of Pharmacy and Technology
Year : 2017, Volume : 10, Issue : 10
First page : ( 3567) Last page : ( 3572)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2017.00646.1

An Review on Floating Mucoadhesive Drug Delivery System

Alai M.S.1,*, Shinkar D.M.1, Saudagar R.B.2

1Department of Pharmaceutics, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, India

2Department of Pharmaceutical Chemistry, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, India

*Corresponding Author E-mail: alaimayur@gmail.com

Online published on 26 March, 2018.

Abstract

A gastro retentive dosage form will release the drug over an extended period in the stomach and upper gastrointestinal tract (GIT) thus enhancing the opportunity for absorption. Various approaches have been proposed to control the gastric residence of drug delivery system in the upper part of the GIT including floating drug delivery system. Formulation of Gastro-Retentive dosage forms (GRDFs) containing suitable drug candidate which would remain in stomach and/or upper part of GIT for prolonged period of time there by is maximizing the drug release at desired site within the time before GRDFs leave the stomach and or upper part of GIT. Oral route has been the adopted and most convenient route for the drug delivery. Floating dosage forms have been developed to float over GI fluids and to release the drug over a desired period of time. Floating drug delivery system also name as hydrodynamically balanced system (HBS). Bioadhesion can be defined as the process by which a natural or a synthetic polymer can adhere to a biological substrate. When the biological substrate is a mucosal layer then, the phenomenon is known as mucoadhesion.

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Keywords

Floating-Mucoadesive Drug delivery system, Gastro retention.

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