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Research Journal of Pharmacy and Technology
Year : 2017, Volume : 10, Issue : 10
First page : ( 3361) Last page : ( 3364)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2017.00597.2

An in silico determination of Drug-Like Molecules from Plant Source to Treat Leprosy-A Neglected Tropical Infectious Disease of India

Sharanya Manoharan*, Radha Mahendran, Suganya Jeyabaskar, Mageshwari R Uma

Department of Bioinformatics, School of Life Sciences, Vels University, Pallavaram, Chennai-600117, Tamil Nadu, India

*Corresponding Author E-mail: sharanya.bioinfo@gmail.com

Online published on 26 March, 2018.

Abstract

In developing countries, awareness towards controlling the infectious diseases with high mortality and morbidity among poor people is neglected. Leprosy otherwise known as Hansen's disease, remains chronic from ancient times which is one among the neglected tropical disease. Though WHO in 1991 set a target to eliminate leprosy by 2000, there are reports recently in 2011 that 41% of cases registered in India. Causative of leprosy is Mycobacterium leprae which affects peripheral nerves, skin and multiple internal organs. Treatment involves the usage of dapsone, a bacteriostatic against M. leprae for many years until the widespread resistant strains occur. Due to which combination therapy emerged where WHO 1998 prescribed rifampicin with dapsone to treat paucibacillary leprosy and rifampicin and/or clofazimine with dapson for multibacillary leprosy. The difficulties in handling the transmission of leprosy bacilli through inhalation or by direct contact, complete eradication of the disease has not been achieved instead severity being increased. In this perspective, the effective, safe and affordable pharmaceuticals has to be discovered from the plant sources, since they act as reservoir from the ancient period and found as one of traditional medicinal system followed. The plants Andrographis paniculata and Ricinus communis having traditional background are selected for the present study in order to predict and identify the bioactive principle through in silico docking analysis. Through the binding score and hydrogen bond formation, the plant compounds for treating leprosy have to be taken further for drug development process.

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Keywords

Neglected Tropical Disease (NTDs), Leprosy, Mycobacterium leprae, Dapsone, Medicinal plants, in silico docking.

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