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Research Journal of Pharmacy and Technology
Year : 2017, Volume : 10, Issue : 1
First page : ( 307) Last page : ( 308)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2017.00062.2

Effect of Hesperidin for its Anti-Proliferative Activity on Liver Cancer and Cardio Vascular Diseases

Dr. Julius A., Vedasendiyar Ramachandran*, Dr. Devakannan Archana, Rajaraman Sujatha, Rangasamy Balamurugan, Saravanan V.

1Professor and Head, Department of Biochemistry, Sree Balaji Dental College and Hospital, Bharath University, Pallikaranai, Chennai-600 100, India

2Research Scholar, Department of Biochemistry, Bharath University and Lab Incharge, Public Health and Preventive Medicine, Govt of Tamilnadu, India

3Medical officer, Public Health and Preventive Medicine, Ashok Nagar, Tamilnadu, India

4Medilink Health Care, Ashok Nagar, Tamilnadu, India

5Senior Scientist, Shree Manakula Vinayagar Medical College and Hospital, Pondicherry, India

6Senior Lecturer, Department of Biochemistry, Sree Balaji Dental college and Hospital, Bharath University, Pallikaranai, Chennai-600 100, India

*Corresponding Author E-mail: drvinraj@gmail.com

Online published on 29 April, 2017.

Abstract

Objective is to study the Plants that have served as a rich source of medicine including anti-cancer drugs. Research has shifted from the study of using extracts of whole or parts of plants to single active principles. Identification of cytotoxic agents led to the development of anticancer therapeutics with significant success but having severe side effects. Recent advances in understanding the molecular basis of cancer and development of high thorough screening methodologies have led to the discovery of novel therapies in the form of target-based drugs. Plant metabolites like flavonoids have fewer side effects and predominantly act by their capacity to scavenge free radicals, enzyme inhibition, and/or antiproliferative activity. Hesperidin is a biologically active flavonoid, is commonly found in citrus fruits and is used in Chinese medicine. It has been shown to have several useful pharmacological properties including blood lipid lowering activity.

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Keywords

Hesperidin, Citrus Fruits, Chemopreventive activity, Liver cancer, Reducing cholesterol.

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