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Research Journal of Pharmacy and Technology
Year : 2017, Volume : 10, Issue : 1
First page : ( 227) Last page : ( 232)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2017.00048.8

Physical Rheological and Cell Viability Study of Some Selected Plant Polysaccharides

Sahu Vikram Kumar1,*, Mishra Amit1, Sharma Nitin2, Sahu Pratap Kumar3, Saraf Shubhini A.4

1Maharana Pratap College of Pharmacy, Kanpur, 209217, India

2Meerut Institute of Engineering and Technology, NH-58, Baghpat Crossing, Partapur Bypass Road, Meerut, 250005, India

3School of Pharmaceutical Sciences, Siksha ‘O ’Anusandhan University, Bhubaneswar, 751030, India

4Department of Pharmaceutical Sciences, Babasaheb Bhimrao Ambedkar University, Lucknow, 226025, India

*Corresponding Author E-mail: vikramsahuknp@gmail.com

Online published on 29 April, 2017.

Abstract

In the present work dry polysaccharides were extracted from two traditional plants, fenugreek (Trigonella Foenum graecum) and tamarind (Tamarindus indica). Both extracted polysaccharide were subjected for several parameter to find out their suitability used as pharmaceutical excipients. Polysaccharides were evaluated for their physicochemical parameters which revealed an acceptable range of micrometric properties. Mean value of total percentage glucose concentration in fenugreek and tamarind was calculated 23.5±4.72 and 31.9±6.32 respectively. Molecular weight of fenugreek and tamarind was estimated by refractive index method which found to be 2.03x10−6 and 1.79 x 106 kg/kg mol respectively. Rheological study indicates that aqueous solution of both polysaccharide possessed non-newtonian pseudoplastic flow behavior. Finally, cell viability assay confirm that both polysaccharide may be considered as safe excipients during drug delivery. The study confirmed that both plat polysaccharides (Trigonella foenum graecum) and (Tamarindus indica) can be considered as effective pharmaceutical excipients for the preparation of novel drug delivery systems.

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Keywords

Trigonella foenum graecumTamarindus indiaca, rheology, Brookfield Rheometer, pseudoplastic.

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