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Research Journal of Pharmacy and Technology
Year : 2017, Volume : 10, Issue : 1
First page : ( 200) Last page : ( 204)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2017.00043.9

Antihyperlipidemic activity of Achyranthes aspera Linn leaves on cholesterol induced hyperlipidemia in rats

Sarvesh C.N.1,*, Fernandes Jennifer2, Janadri Suresh3, Yogesh H.S.1, Swamy Shivakumar1

1Department of Pharmacology, Mallige College of Pharmacy, Bengaluru, Karnataka, India

2Department of Pharmacology, Nitte Gulabi Shetty Memorial Institute of Pharmaceutical Sciences, Deralakatte, Mangalore

3Department of Pharmacology, Acharya and B M Reddy College of Pharmacy, Bengaluru, Karnataka, India

*Corresponding Author E-mail: cnsarvesh@yahoo.co.in

Online published on 29 April, 2017.

Abstract

Plants have been one of the important sources of medicines since the beginning of human civilization. Achyranthes aspera Linn. (A.aspera) belonging to family Amaranthaceae, commonly found in India. The plant is used as antiarthritic, purgative, diuretic and antimalarial etc. The antihyperlipidemic activity of alcoholic and aqueous extracts of leaves of A.aspera was evaluated using cholesterol induced hyperlipidemia in albino wistar rats. In this model, 8 groups consist of 6 animals per group. Group I and II were considered as saline and hyperlipidemic controls respectively, and groups III-VIII received respective treatment (ethanolic extract 250 mg, 500 mg, aqueous extract 250mg, 500 mg, Ayurvedic preparation and atorvastatin). All the groups received cholesterol (400 mg/kg b.w. p.o) except saline control for 4 weeks. The serum HDL, LDL, TG, and TC levels were analyzed in cholesterol induced hyperlipidemia where both the extracts of ethanolic and aqueous extract were shown antihyperlipidemic activity compared to hyperlipidemic control.

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Keywords

Achyranthes aspera, cholesterol, HDL, LDL, TG, TC, Antihyperlipidemic.

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