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Research Journal of Pharmacy and Technology
Year : 2017, Volume : 10, Issue : 1
First page : ( 135) Last page : ( 140)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2017.00030.0

Pharmacokinetics of Tacrine Loaded MPEG-PCL Polymeric Nanoparticles

Kumar S. Sathesh*, Joe V. Felix

Department of Pharmaceutics, School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies (VISTAS), Vels University, Pallavaram, Chennai-600117, Tamilnadu, India

*Corresponding Author E-mail: sathesh2000@gmail.com

Online published on 29 April, 2017.

Abstract

The Tacrine loaded mPEG-PCL nanoparticles were prepared by emulsion polymerization and solvent evaporation method, to improve the bioavailability of the drug in brain. The nanoparticulate formulation was characterized for particles size, encapsulation efficiency, zeta potential and in vitro release study. The pharmacokinetic studies of Tacrine-loaded mPEG-PCL nanoparticles were carried out in Sprague dawley rats. The study revealed Cmax and Tmax were significantly altered and Clearance was less in brain and blood when compared to that of plain Tacrine solution. These results suggest that mPEG-PCL nanoparticles had considerably increased the transport of Tacrine across the BBB.

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Keywords

Alzheimer's disease, Tacrine, Blood Brain Barrier (BBB), Emulsion Polymerization method, Nanoparticles.

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