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Research Journal of Pharmacy and Technology
Year : 2017, Volume : 10, Issue : 1
First page : ( 98) Last page : ( 100)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2017.00023.3

Synthesis and Antimicrobial Evaluation of Substituted Oxazolidinones Moieties

Kumar Pankaj*, Fernandes Jennifer, Kumar Abhishek

Department of Pharmaceutical Chemistry, NGSM Institute of Pharmaceutical Sciences, Nitte University, Paneer, Deralakatte-575018, Mangalore, Karnataka

*Corresponding Author E-mail: pankaj@gmail.com

Online published on 29 April, 2017.

Abstract

In order to develop relatively small molecules as pharmacologically active molecules, a series of oxazolidinones having benzo thiazinen moieties and their derivatives were synthesized, and characterized by IR, 1H NMR and Mass spectral studies. Oxazolidinones were prepared from R-glycidylbutarate and Para bromo aniline. Various substituted oxazolidinones benzo thiazinen were prepared by simple reflux in the presence of acetonitrile. Treatment of these oxazolidinones benzo thiazinen deravatives with methanesulfonyl gives its sulphonates derivatives on further treatment with sodium azide and tri phenyl phosphine in acetic anhydride to give its acetamide derivatives. All the newly synthesized compounds were evaluated for antibacterial activity against Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa.

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Keywords

Oxazolidinones, Benzothiazinen, Antibacterial, Antifungal.

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