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Research Journal of Pharmacology and Pharmacodynamics
Year : 2017, Volume : 9, Issue : 4
First page : ( 189) Last page : ( 194)
Print ISSN : 0975-4407. Online ISSN : 2321-5836.
Article DOI : 10.5958/2321-5836.2017.00033.7

Hepatoprotective and Anti-inflammatory activities of Hydroalcoholic extract of Bark of Erythrina indica

Shah Vrunda V.1,*, Shah Vipul K.2, Sheth N. R.3, Patel M. M.4

1M. Pharm, Ph. D Running, Department of Pharmacognosy, Shree Swaminarayan Sanskar Pharmacy College, Zundal, Gandhinagar-382421, Gujarat, India

2M. Pharm, Ph. D Running, Troikaa Pharmaceuticals Ltd., Ahmedabad, Gujarat, India

3M. Pharm, Ph. D, Vice Chancellor of Gujarat Technological University, Ahmedabad, Gujarat, India

4M. Pharm, Ph. D, Director, Shree Swaminarayan Sanskar Pharmacy College, Zundal, Gandhinagar, Gujarat, India

*Corresponding Author E-mail: vrundazalavadiya@gmail.com

Online published on 24 May, 2018.

Abstract

Background

Natural remedies from medicinal plants are considered to be effective and safe alternative treatment for liver toxicity and inflammation.

Aim

This present work was done to investigate the Hepatoprotective and Anti-inflammatory activities of Hydroalcoholic extract of Bark of Erythrina indica.

Materials and Methods

Drugs like Silymarin, Carbon tetrachloride, Liquid paraffin, carrageenan, Aspirin were used. For Hepatoprotective activity SGOT, SGPT, ALKP, Total cholesterol, Total bilirubin, Albumin, Total protein Estimation kit and for anti-inflammatory activity carrageenan-induced paw oedema method were used.

Result and discussion

The hepatoprotective activity of the Hydroalcoholic extract was assessed in CCl4 induced hepatotoxic Rats. The extract of plant (300mg/kg and 500mg/kg, orally) was given for 6 days, daily and CCl4 (1 ml/kg, 1: 1 with liquid paraffin, s.c.) was given at 6th day after dosing of plant extract. Alteration in the levels of biochemical markers of hepatic damage like SGOT, SGPT, ALKP, Bilirubin, Cholesterol, Total Protein and Albumin were tested in both CCl4 treated and untreated groups. CCl4 has enhanced the SGOT, SGPT, ALKP and Bilirubin in serum, while Total protein and Albumin were decreased. The study was also supported by histopathology of liver sections. Treatment of Hydroalcoholic extract of Bark of Erythrina indica has brought back the altered levels of biochemical markers to near about normal levels in the dose dependent manner. Antiinflammatory activity was done in rats at a dose 300 and 500 mg/kg in carrageenan-induced paw oedema method. Hydroalcoholic extract of Erythrinaindica bark significantly reduced the migration of neutrophils and monocytes. Results of in vivo activity lead to the conclusion that the hydroalcoholic extract of Erythrinaindica bark showed predominantly significant activity in dose dependent manner, which is comparable to the standard drug Aspirin. The present study reveals that the Hydroalcoholic extract of Bark of Erythrinaindica could afford a significant Hepatoprotective and Anti-inflammatory activity.

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Keywords

Erythrina indica, CCl4, SGOT, SGPT, ALKP, Aspirin, carrageenan.

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