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Research Journal of Pharmacology and Pharmacodynamics
Year : 2017, Volume : 9, Issue : 3
First page : ( 157) Last page : ( 166)
Print ISSN : 0975-4407. Online ISSN : 2321-5836.
Article DOI : 10.5958/2321-5836.2017.00027.1

Current Concepts in Clinical Based Management of Diabetic Foot Infections: A Review

Prasad Jhakeshwar*, Netam Ashish Kumar, Sahu Mahendra Kumar, Satapathy Trilochan

Department of Pharmacology, Columbia Institute of Pharmacy, Tekari, Near Vidhansabha, Raipur-493111 Dist-Raipur (C.G.) India

*Corresponding Author E-mail: jhakeshwarprasad03@gmail.com

Online published on 24 May, 2018.

Abstract

Diabetic foot ulcers (DFUs) are potentially mortifying complications in need of multidisciplinary endeavour. Imbalance of harmony in glucose homeostasis causes hyperglycemic status which in turn leads to activation of certain metabolic pathways subsequently that lead to development of vascular insufficiency, nerve damages headed by ulceration in lower extremity due to plantar pressures and foot deformity. The standard of care for DFUs consists of several conventional treatments such as, daily wound care dressings, off loading, infection control, glucose control and adequate Perfusion etc. Still the reported healing rate varied between 20.0% and 46.2%. So some newly invented therapies such as negative pressure therapy, topical therapies, hyperbaric oxygen therapy, growth factors, and other antibiotic therapies took upper hand over the conventionally used medications for the treatment of diabetic foot infections. These new therapies also bring about new opportunities for DFU patients. In this review our efforts have been devoted to summarize the various treatments available along with possible mechanism of action for the effective treatment of diabetic foot ulcers.

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Keywords

Diabetic foot infections, Diagnosis, Becaplermin, PDGF, Antibiotic therapy.

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