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Research Journal of Pharmacology and Pharmacodynamics
Year : 2017, Volume : 9, Issue : 3
First page : ( 142) Last page : ( 146)
Print ISSN : 0975-4407. Online ISSN : 2321-5836.
Article DOI : 10.5958/2321-5836.2017.00024.6

Antihyperlipidemic activity in aqueous leaf extract of Ciceracida in Wistar Albino Rats

Hoque Mohibul1, Dr. Satish S2

1Research Scholars, JJT University, Jhunjhunu, Rajasthan, India

2Department of Pharmaceutical Science, JJT University, Jhunjhunu, Rajasthan

Online published on 24 May, 2018.

Abstract

Hyperlipidemia is a major cause of Atherosclerosis and the atherosclerosis-associated condition such as coronary heart disease ischemic cerebrovascular disease and peripheral vascular disease. The present study was carried out to investigate antihyperlipidemic properties of aqueous leaf extract of ciceracida (ALEC) against hyperlipidemia induced by high fat diet (HFD) in wistar albino rats. Wistar albino rats were divided in 6 groups of 6 rats in each. Group I received normal diet. Group II received high fat diet. Group III received a high fat diet supplemented with simvastatin 4mg/kg. Group IV received high fat diet supplemented with aqueous leaves extract of ciceracida 100 mg/kg. Group V received a high fat diet supplemented with aqueous leaves extract of ciceracida 250 mg/kg and Group VI received a high fat diet supplemented with aqueous leaves extract of ciceracida 500mg/kg for 30 days. At the end of the experiments on the 30th, day blood samples was collected 4 h after the last dose of administration using light ether anesthesia. Blood samples were collected separately from retro orbital sinus puncture into sterilized dry centrifugation tubes. Blood serum was analysed for its hypolipidemic activity. Serum analysis showed decrease cholesterol, triglyceride, low density lipoprotein, very low density lipoprotein, atherogenic index, body weight, food intake and an increase cholesterol excretion and serum high density lipoprotein content was observed in the group III, IV, V and VI rats as compared to the group II rats, and there is no histopatholological alteration in rat aorta was seen. Thus it could be concluded that ALEC is potent antihyperlipidemic activity.

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Keywords

Ciceracida leaf, Lipoprotein, Hyperlipidemic diet, Obesity.

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