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Research Journal of Pharmacology and Pharmacodynamics
Year : 2017, Volume : 9, Issue : 1
First page : ( 13) Last page : ( 18)
Print ISSN : 0975-4407. Online ISSN : 2321-5836.
Article DOI : 10.5958/2321-5836.2017.00003.9

Synthesis, characterization and biological evaluation of some novel substituted 1, 3-thaizine derivatives

Muppavarapu Srinivasa Murthy, Bairam Ravindar*

Department of Pharmaceutical Chemistry, Vignan Institute of Pharmaceutical Sciences, Near Ramoji Film City, Deshmukhi, Nalgonda, Telangana-508284, India

*Corresponding Author E-mail: ravindarpharma@gmail.com

Online published on 26 April, 2017.

Abstract

Thiazine derivatives are an important class of heterocyclic compounds and reported to possess a wide spectrum of biological properties. Thiazines exerted important anticonvulsant activity in models of generalized seizure which were well documented in the literature and therefore new thiazines were synthesized with an aim to get potent anticonvulsant agents. 4-methyl Cyclohexanone on Claisen-Schmidt condensation with various aromatic aldehydes in presence of dilute sodium hydroxide afforded the corresponding 2, 6-disubstitutedarylidene cyclohexanones. Further these compounds were subjected to cyclocondensation with thiourea, catalyzed by aqueous potassium hydroxide to form 4-substitutedaryl-8-substitutedarylidene-2-imino-6-methyl-5, 6-dihydro4H, 7H (3, 1) benzothiazines. The structure of synthesized compounds were characterized by their UV, IR, 1H NMR and Mass spectral data as well as elemental analyses and newly synthesized final compounds were evaluated for their antimicrobial & anticonvulsant activity by PTZ induced method, using ciprofloxacin, fluconazole and diazepam as standard drugs.

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Keywords

Chalcones, Thiazine, Antimicrobial Activity, Anticonvulsant Activity.

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