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Research Journal of Pharmacology and Pharmacodynamics
Year : 2016, Volume : 8, Issue : 3
First page : ( 118) Last page : ( 122)
Print ISSN : 0975-4407. Online ISSN : 2321-5836.
Article DOI : 10.5958/2321-5836.2016.00022.7

Evaluation of Anthelmintic Activity of the Chloroform and Aqueous Extracts of leaves of Couroupita guianensis on Pheretima posthuma by Worm Motility Assay Method

Uppala Praveen Kumar*, Krishna Murali, Kumar B. K. Atchuta, Ramji D.J. Vinay

Bhaskara Institute of Pharmacy, Bobbili, Vizianagaram District

*Corresponding Author E-mail: praveen.chintu32@gmail.com

Online published on 18 October, 2016.

Abstract

Objective

To investigate Anthelmintic Activity of the Chloroform and Aqueous Extracts of leaves of Couroupita guianensis on Pheretima posthuma by Worm Motility Assay Method

Methods

The Anthelmintic activity of the Aqueous and Chloroform Extracts of Leaves of Couroupita guianensis on Pheretima posthuma by Worm Motility Assay Method and the results were compared for the both extracts. Anthelmintic activity is compared with standard drug Albendazole.

Results

The chloroform extract showed better anthelmintic activity at a concentration of 200 mg/ml, whereas the aqueous extract also showed paralysis and death at similar concentrations against Indian earth worms. The other test concentrations of both the extracts showed marked degree of anthelmintic activity. The anthelmintic effect of extracts is comparable with that of the effect produced by the standard drug albendazole.

Conclusion

From the above finding concluding that, the plant possesses significant anthelmintic activity at 200 mg/ml concentration measured by time taken for paralyse/death of the earth worms. The current investigation leads to conclusion that the leaves of Couroupita guianensis have potent anthelmintic activity when compared with the conventionally used drug

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Keywords

Couroupita guianensis, Anthelmintic, Pheretima posthuma, Worm Motility Assay Method.

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