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Research Journal of Pharmacology and Pharmacodynamics
Year : 2016, Volume : 8, Issue : 3
First page : ( 111) Last page : ( 114)
Print ISSN : 0975-4407. Online ISSN : 2321-5836.
Article DOI : 10.5958/2321-5836.2016.00020.3

Evaluation of Nootropic activity Potential of Krill Oil in Diazepam Induced Amnesic Mice

Jayanth P. C.*, Kar Prasanna Kumar, Babu M. Niranjan

Department of Pharmacology, Seven Hills College of Pharmacy, Venkataramapuram, Tirupati-517561

*Corresponding Author E-mail: jayanthpharmacy@gmail.com

Online published on 18 October, 2016.

Abstract

The present study was carried to evaluate the nootropic activity potential of krill oil using diazepam (5mg/kg) induced amnesia in mice. Nootropic activity was evaluated using radial arm maze (RAM), Y-maze, Morris water maze were employed to evaluate the activity. The results demonstrated that the percentage of memory increased was comparable with that of standard drug piracetam (20mg/kg). It was observed that there was increase in 45.29% of memory when it was tested in radial arm maze (RAM) and the escape latency was quantified using Morris water maze was gradually decreased from Day 0 to Day 14 i.e. 38.5 ± 0.76 to 13.22 ± 0.31, there was 89.4% of memory increased when the treated animals were tested in Y maze. So by the above results it is concluded that krill oil possess the nootropic activity. So this drug can be used for the various amnesic disorders like Short term memory loss, Alzheimers disease etc.

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Keywords

Diazepam, Piracetam, radial arm maze, Morris water maze, Y maze.

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