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Research Journal of Pharmacology and Pharmacodynamics
Year : 2016, Volume : 8, Issue : 2
First page : ( 58) Last page : ( 64)
Print ISSN : 0975-4407. Online ISSN : 2321-5836.
Article DOI : 10.5958/2321-5836.2016.00011.2

Effect of Prenatal Exposure of Clobazam on Anxiety Parameters in Rat Offspring

Jaiswal Arun Kumar1,*

Neuropharmacology Laboratory, Department of Pharmacology, Institute of Medical Sciences, Banaras Hindu University, Varanasi-221005, India

1Department of Psychology, Faculty of Social Sciences, Mahatma Gandhi Kashi Vidyapith, Varanasi, 221002

*Corresponding Author E-mail: arunjais@rediffmail.com

Online published on 21 July, 2016.

Abstract

Behavioural teratological effects of prenatal clobazam exposure were investigated on anxiety parameters in rats. Pregnant rats were administered clobazam (0.5, 1, 2 and 5 mg/kg/day) orally once a day during the gestation days 13 to 20. The pups born were subjected to open-field exploratory behaviour, elevated plus maze and elevated zero maze tests at 8 weeks of age. The results indicated that prenatal clobazam treatment (0.5, 1, 2 and 5 mg/kg/day) induced significant increase in open-field ambulation, rearings and self-grooming in rat offspring. Rat offspring treated with different doses of clobazam during the prenatal period displayed dose dependent significant increase in anxiogenic behaviour patterns on elevated plus maze and elevated zero maze in comparison to control rat offspring. The findings highlight that prenatal clobazam treatment induced persistent behavioural alterations on anxiety parameters in the rat offspring.

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Keywords

Clobazam, Anxiety, Elevated plus maze, Elevated zero maze, Open-field, Prenatal, Rat.

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