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Research Journal of Pharmacology and Pharmacodynamics
Year : 2016, Volume : 8, Issue : 1
First page : ( 13) Last page : ( 16)
Print ISSN : 0975-4407. Online ISSN : 2321-5836.
Article DOI : 10.5958/2321-5836.2016.00004.5

Diuretic Activity of Fruit Extract of Xanthium strumarium L in Albino Rats

Halkai M.A.1, Patil Arun1,*, Ahmed MD Akhil1, Beknal AK1

1Department of Pharmacognosy, HKES's College of Pharmacy, Gulbarga, Karnataka, India-585 105

*Corresponding Author E-mail: asp_room@rediffmail.com

Online published on 18 April, 2016.

Abstract

Objective

The present study is an attempt to investigate the diuretic effect of fruit extracts, phytochemical screening, isolation and identification of phytoconstituents from petroleum ether, benzene, chloroform, alcohol and aqueous extracts of Xanthium strumarium.

Materials and Methods

The animals were divided into four groups each. Group-I was treated only with normal saline solution and serve as control. Group-II was received furosemide at a dose of 5 mg/Kg, p.o. and it was considered as positive control group. Group-III & Group-IV received the petroleum ether extract (PEE) at doses of 250 and 500mg/Kg, p.o. respectively. After oral administration of PEE, the urinary output of each group was recorded at different time intervals from the graduated urine chamber at metabolic cage. The volume of urine collected was measured at the end of 5 h.

Results

We observed a potent diuretic and electrolyte activity in petroleum ether extract of Xanthium strumarium L fruits. The Diuretic activity was not observed in chloroform and alcoholic extracts.

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Keywords

Diuretic activity, Xanthium strumarium L fruits, Furosemide.

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