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Research Journal of Pharmacology and Pharmacodynamics
Year : 2015, Volume : 7, Issue : 4
First page : ( 184) Last page : ( 186)
Print ISSN : 0975-4407. Online ISSN : 2321-5836.
Article DOI : 10.5958/2321-5836.2015.00037.3

Evaluation of Antidiarrhoeal Activity Cleome gynandra Leaf Extracts on Magnesium Sulphate-and Castor Oil-Induced Diarrhoea in Wistar Rats

Reddy Nadiminti Satish*, Santhosha D., Vidyasabbani, Reddy P. Vishwanath, Venu Ch.

Department of Pharmacology, Vishnu Institute of Pharmaceutical Education and Research, Vishnupur, Narsapur, Medak, Telangana, India

*Corresponding Author E-mail: satishreddy949@gmail.com

Online published on 8 December, 2015.

Abstract

The methanolic extract leaves of Cleome gynandra (Family Capparidaceae) was selected to evaluate the antidiarrhoeal activity against castor oil and magnesium sulphate induced diarrhoea in wistar albino rats. The present study was performed at three different doses of 100 mg/kg, 200mg/kg and 400mg/kg methanolic extract of plant. The Methanolic plant extracts shows more effective antidiarrhoeal activity against castor-oil induced diarrhea compared to magnesium sulphate induced diarrhoea in a dose dependent manner. From the results we conclude that methanolic leaf extracts of Cleome gynandra had reported antidiarrhoeal activity similar to standard drug loperamaide at dose of 3 mg/kg.

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Keywords

Cleome gynandra, antidiarrhoeal activity, Loperamide, Castor oil, Magnesium sulphate.

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