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Research Journal of Pharmacology and Pharmacodynamics
Year : 2015, Volume : 7, Issue : 4
First page : ( 155) Last page : ( 160)
Print ISSN : 0975-4407. Online ISSN : 2321-5836.
Article DOI : 10.5958/2321-5836.2015.00030.0

Experimental Evaluation of Antiepileptic Activity of Amalakyadi Ghrita

Rupali Kale C.1, Swati Gadgil S.2,*, Kanchan Borole D.3, Asmita Wele A.4

1Ayurved Practitioner, Pune

2Assistant Professor, Department of Rasashastra Bhaishajyakalpana, College of Ayurved, Bharati Vidyapeeth Deemed University, Pune

3Assistant Professor, Pharmacology Dept., Bharati Vidyapeeth Deemed University, Medical College, Pune

4Professor and HOD, Department of Rasashastra Bhaishajyakalpana and Dean, Bharati Vidyapeeth Deemed University, College of Ayurved, Pune

*Corresponding Author E-mail: vd.swatigadgil@gmail.com

Online published on 8 December, 2015.

Abstract

Amalakyadi Ghrita (AG) a ghee based formulation is recommended for the treatment of Apasmar (Epilepsy) in Ayurved. Present study has been designed to prepare standard Amalakyadi Ghrita and evaluate it's antiepileptic activity using animal models namely Maximal Electricshock Seizures (MES) and Pentelenetetrazole (PTZ) induced seizure. It has been prepared, standardised using analytical tests and subjected to preliminary phytochemical analysis. Control drug, i.e. Cow ghee 5gm/kg, Standard drug, i.e. Phenytoin 25mg/kg and AG at three dose levels 2.5gm/kg, 5gm/kg and 10gm/kg. were administered orally in all the models. Mean values and standard error of mean was determined for all models and data was analyzed by one-way ANOVA, followed by Dunnett's test. Preliminary phytochemical analysis of AG showed presence of alkaloids, phenols, tannins and flavonoids. AG at medium and higher dose exhibited significant antiepileptic activity in MES model by decreasing the duration of tonic extensor phase (p<0.001). In PTZ model, AG at higher dose, significantly delayed the onset of convulsions (p<0.05). AG has shown significant anticonvulsant activity in both the study models. The presence of different phyto constituents in the formulation may singularly or in combination be responsible for this activity.

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Keywords

Amalakyadi Ghrita, Antiepileptic Activity, Apasmar, Ayurved, MES, PTZ.

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