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Research Journal of Pharmacology and Pharmacodynamics
Year : 2015, Volume : 7, Issue : 1
First page : ( 29) Last page : ( 34)
Print ISSN : 0975-4407. Online ISSN : 2321-5836.
Article DOI : 10.5958/2321-5836.2015.00007.5

Hepatoprotective activity of chenopodium album Linn. in carbon tetrachloride induced hepatotoxicity rats

Karwani Gauri, Sisodia Siddhraj S.*

Bhupal Nobles’ College of Pharmacy, Udaipur, Rajasthan, 313 001, India

*Corresponding Author E-mail: sisodiabn@yahoo.co.in

Online published on 2 May, 2015.

Abstract

Chenopodium album Linn. is a commonly used herbal drug against many diseases. The hepatoprotective activity of hydroalcoholic extract of dried powder of leaves plant of Chenopodium album Linn. was investigated in hepatotoxicity rat model. Hepatotoxicity was induced in Wistar rats by intraperitoneal injection of carbon tetrachloride. Different doses were tested to decide the dose related hepatoprotective efficacy of Chenopodium album Linn. (200 mg/kg, 400 mg/kg, 600 mg/kg body weight/day po for two weeks). The Hepatoprotective effect of these extracts was evaluated by liver function biochemical parameters (i. e. total bilirubin, total cholesterol, total protein, serum glutamateoxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT) and alkaline phosphatase and In Vivo antioxidant enzyme superoxide dismutase (SOD), reduced glutathione (GSH), lipid peroxidases (LPO) and catalase activities) and histopathological examination of liver. In extract-treated animals, the toxicity effect of carbon tetrachloride was controlled significantly by restoration of the levels of serum biochemical parameters as compared to the normal and standard drug silymarin treated groups. Histology of liver sections of the animals treated with the extracts showed the hepatic cell regeneration. Therefore, the results of present study support the hepatoprotective effect of Chenopodium album Linn.

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Keywords

Chenopodium album Linn, Hepatotoxicity, Hepatoprotective, Carbon tetrachloride.

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