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Research Journal of Pharmacology and Pharmacodynamics
Year : 2012, Volume : 4, Issue : 5
First page : ( 278) Last page : ( 280)
Print ISSN : 0975-4407. Online ISSN : 0000-0000.

Diuretic and laxative activity of ethanolic extract of Mollugo pentaphylla Linn.

Sahu S.K.1,*, Das D.2, Tripathy N.K.1, Kumar H.K. Sundeep1

1School of Pharmaceutical Science & Research, Berhampur University, Berhampur, Odisha –760007

2School of Pharmaceutical Sciences, SOA University, Bhubaneswar, Odisha-754030

*Corresponding Author: S. K. Sahu, School of Pharmaceutical Science & Research, Berhampur University, Berhampur, Odisha –760007. E-mail- sujitkumar_2008@yahoo.com

Online published on 21 February, 2013.

Abstract

Crude ethanolic extract of Mollugo pentaphylla Linn. (family-Aizoaceae) was investigated for diuretic and laxative activity in albino rats at 200 and 400 mg/kg p.o. Which was compared with standard drugs Furosemide (10mg/kg, p.o.) and Agar agar (300mg/kg, p.o.) respectively. The extract was found to produce significant diuretic as well as laxative activity at dose 400 mg/kg. The plant was also found to possess the phytoconstituents like carbohydrates, alkaloids, gums, saponins, flavanoids, tanins and steroids.

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Keywords

Mollugo pentaphylla, Acute toxicity study, Diuretic activity, Laxative activity.

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