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Research Journal of Pharmacology and Pharmacodynamics
Year : 2012, Volume : 4, Issue : 2
First page : ( 111) Last page : ( 115)
Print ISSN : 0975-4407. Online ISSN : 0000-0000.

Pharmacological Investigation of Methanolic Extract of Ficus glomerata Linn. Bark

Rumzhum Nowshin Nowaz*, Md. Rahman Mostafizur, Chowdhury Sadia A., Parvin Most. Nazma, Hasan Mahabub

Laboratory of Pharmacognosy and Pharmacology, Department of Pharmacy, Stamford University Bangladesh, Dhaka-1217, Bangladesh

*Corresponding Author: Nowshin Nowaz Rumzhum, Lecturer Department of Pharmacy Stamford University Bangladesh 51, Siddeswari road Dhaka-1217, Bangladesh Phone: +88-01715374893 E-mail: address: nowshin.nowaz@yahoo.com

Online published on 21 February, 2013.

Abstract

The methanolic extract of the bark of Ficus glomerata Linn. (Family: Moraceae) was evaluated for in vitro antioxidant activity by determination of hydrogen peroxide scavenging activity, total antioxidant capacity, assay of nitric oxide scavenging activity and reducing power test and in vivo antinociceptive effect in acetic acid induced writhing model in Swiss albino mice. The plant extract was also subjected for brine shrimp lethality bioassay to evaluate its cytotoxic property. The results revealed the presence of pronounced antioxidant property as compared with ascorbic acid used as standard and a dose-dependent (250 and 500 mg/kg) analgesic effect. Investigation also showed that it has strong lelthality (LC50 1.247 μg/ml) against brine shrimp nauplii, Vincristine Sulphate was used as positive control. The antioxidant, antinociceptive and cytotoxic properties observed seem to be in good accordance with the traditional uses of Ficus glomerata.

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Keywords

Ficus glomerata Linn, Moraceae, Antioxidant, Antinociceptive, Cytotoxicity.

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