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Research Journal of Pharmacology and Pharmacodynamics
Year : 2011, Volume : 3, Issue : 3
First page : ( 140) Last page : ( 147)
Print ISSN : 0975-4407.

Multidose Therapy (MDT) Treatment for Helicobacter Pylori Infection Leading To Gastric Ulcer and Carcinoma: A Review.

Alexander Amit*, Tripathi D. K.,  Ajazuddin, Singh Mukesh, Sahu Monesh,  Swarna

Rungta College of Pharmaceutical Sciences and Research, Bhilai

*Corresponding Author: Amit Alexander, Assistant Professor, Department of Pharmaceutics Rungta College of Pharmaceutical Sciences and Research, Bhilai. Mob. No: 09907333846, E-mail: mailme_amitalex@yahoo.in, itsmeamitalex@gmail.com

Online published on 20 March, 2013.

Abstract

The realization that Helicobacter pylori is one of the most important etiological factors for peptic ulcer has had an enormous impact on approach to the management of ulcer disease leading to gastritis, gastric cancer and duodenal ulcer which has been a major problem in India as well as western and southern country. Helicobacter pylori is one of the microorganism which can easily survive in highly acidic medium in gastrointestinal tract even though they can survive in acid of car battery; so, there are various treatment schedules just like single, double and triple drug therapy including antibiotics, proton pump inhibitors, antacids, antiamoebic and H2 blockers. These drugs are used in the combination therapy for a specific period of time and high eradication rate 86–90% of Helicobacter pylori is observed in case of triple drug therapy, for the best result triple drug therapy (proton pump inhibitors, antibiotics & H2 blockers) along with antacids must be employed in the treatment of Helicobacter pylori infection leading to gastric ulcer and gastric carcinoma because triple drug therapy reduces total duration of therapy.

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Keywords

H. pylori, gastritis, duodenal ulcer, gastric carcinoma.

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