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Research Journal of Pharmacology and Pharmacodynamics
Year : 2019, Volume : 11, Issue : 4
First page : ( 153) Last page : ( 158)
Print ISSN : 0975-4407. Online ISSN : 2321-5836.
Article DOI : 10.5958/2321-5836.2019.00027.2

A Review on Drug-drug Interaction Studies of Spiranolactone and Telmisartan

Swapna G., Poojitha J.*, Pravallika B.

Department of Pharmaceutical Analysis, Nirmala College of Pharmacy, Atmakuru, Guntur District-522503

*Corresponding Author E-mail: poojithajammalamudi97@gmail.com

Online published on 31 December, 2019.

Abstract

A drug interaction is a change in the action or side effects of a drug caused by concomitant Administration with a food, beverage, supplement, or another drug. There are many causes of drug interactions. For example, one drug may alter the pharmacokinetics of another. Alternatively, drug interactions may result from competition for a single receptor or signalling pathway. The risk of a drug-drug interaction increases with the number of drugs used. Over a third (36%) of the elderly in the U.S. regularly use five or more medications or supplements, and 15% are at potential risk of a significant drug-drug interaction. Drug interactions can have desired, reduced or unwanted effects. The probability of interactions increases with the number of drugs taken. The high rate of prescribed drugs in elderly patients (65-year-old patients take an average of 5 drugs) increases the likelihood of drug interactions and thus the risk that drugs themselves can be the cause of hospitalization. There are many causes of drug interactions. For example, one drug may alter the pharmacokinetics, absorption, distribution, metabolism, or excretion (ADME) of another. The risk of a drug interaction occurring increases as the number of drugs administered to a patient increases. Similarly the drug interaction studies of spiranolactone which is a potassium-sparing diuretics and telmisartan which is an angiotensin receptor blockers is known in this. And the qualitative and quantitative analysis of the two drugs is also studied in this.

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Keywords

Spiranolactone, telmisartan, validation, stability study, RP-HPLC, LC-MS.

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