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Research Journal of Pharmacology and Pharmacodynamics
Year : 2019, Volume : 11, Issue : 3
First page : ( 83) Last page : ( 88)
Print ISSN : 0975-4407. Online ISSN : 2321-5836.
Article DOI : 10.5958/2321-5836.2019.00014.4

Pharmacological Evaluation of Livodac Tablet on Paracetamol induced Hepatotoxicity Models in Wistar rats

Jagtap Pradnya. N.1,*, Chavan Prachali Ramdas2

1Pune District Education Association's, Seth Govind Raghunath Sable College of Pharmacy, Saswad, 412301, Tal. Purandar, Dist. Pune, Maharashtra, India

2M. Pharm (Pharmacology Department), Pune District Education Association's, Seth Govind Raghunath Sable College of Pharmacy, Saswad, 412301, Tal. Purandar, Dist. Pune, Maharashtra, India

*Corresponding Author E-mail: prachalichavan@gmail.com

Online published on 31 December, 2019.

Abstract

The present study was conducted to evaluate the Hepatoprotective activity of livodac tablet against Paracetamol induced liver cirrhosis in Wistar rats. The livodac tablet (100, 200 and 400mg/kg) was administered orally to the animals with hepatotoxicity induced by Paracetamol (2gm/kg). Silyamarin (54mg/kg) was given as reference standard. The livodac tablet was effective in protecting the liver against the hepatotoxicity induced by Paracetamol in rats. This was evident from significant reduction in serum enzymes alkaline phosphate, total Bilirubin, total protein, serum glutamic-oxaloacetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT). It was concluded from the result the livodac tablet was Hepatoprotective activity against Paracetamol induced hepatotoxicity in rats.

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Keywords

Livodac Tablet, Paracetamol, Hepatoprotectiveand Hepatotoxicity.

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