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Research Journal of Pharmacology and Pharmacodynamics
Year : 2019, Volume : 11, Issue : 1
First page : ( 46) Last page : ( 52)
Print ISSN : 0975-4407. Online ISSN : 2321-5836.
Article DOI : 10.5958/2321-5836.2019.00009.0

Therapeutic Approaches for the Management of Parkinson's Disease

Prasad Jhakeshwar*, Netam Ashish Kumar, Singh Ritika, Sahu Manisha, Satapathy Trilochan, Rao S. Prakash, Baghel Purnima, Sahu Mahendra Kumar

Columbia Institute of Pharmacy, Tekari, Raipur (CG), pin 493111

*Corresponding Author E-mail: jhakeshwarprasad03@gmail.com

Online published on 16 March, 2019.

Abstract

Parkinson‘s disease (PD) is a chronic, neuro generative and movement disorder, which involves progressive fall of motor function due to loss of dopamine producing cells particularly in the substantial nigra area of the brain. It is the most common neurodegenerative disorder, which develops gradually and the symptoms may worsen over the time. It is characterized by progressive loss of muscle control leading to rigidity, tremors and hypokinesia. It has an interesting pathophysiology in which acetylcholine shows hyperactivity. In recent times, the important role of oxidative stress in neurological deformity, including Parkinson‘s disease, have been mostlyexhort. The progression of PD and the degree of impairment vary from individual to individual. Most individuals who develop PD are 60 years or older. Men are one and a half times more likely to have PD than women. More than 10 million people worldwide are living with PD. Some people with PD live long productive lives, but others grow to bedisablea good dealextrarapidly. Hallmarks of PD include protein α-synuclein also called Lewy bodies found not only in midbrain but also in the brain stem and olfactory bulb. Although there is no cure available for this disease some drugs like Levodopa and Carbidopa proved partially effective. Herbal approaches can be a new advancement in this field. When it comes to the effectiveness of medicines and traditional medicines, often over time, the response to Parkinson's symptoms will stop responding. We suggest that treatment with herbal-based medicines may be a fruitful approach for the management of PD.

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Keywords

Parkinson‘s disease, Neurogenerative disorder, Antioxidant remedies, Herbal medicines.

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