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Research Journal of Pharmacology and Pharmacodynamics
Year : 2019, Volume : 11, Issue : 1
First page : ( 32) Last page : ( 36)
Print ISSN : 0975-4407. Online ISSN : 2321-5836.
Article DOI : 10.5958/2321-5836.2019.00007.7

Evaluation of Immunomodulatory Potentials of The Leaves of Aquilaria malaccensis

Hegde Karunakar*, Shree Durga P M, Sajjan Praveenkumar C

Department of Pharmacology, Srinivas College of Pharmacy, Valachill, Post-Farangepete, Mangalore-574143, Karnataka, India

*Corresponding Author E-mail: khegde_sh2003@yahoo.co.in

Online published on 16 March, 2019.

Abstract

In the present study the ethanolic extract of the leaves of Aquilaria malaccensis was evaluated for immunomodulatory effect against cyclophosphamide and sheep RBC induced immune response in rats. The oral acute toxicity study conducted with extract was found to be safe and non-toxic at a dose of 2000 mg/kg. The two doses of extract 200 mg/kg and 400 mg/kg, p.o. was tested for immunomodulatory effect by assessing immune response, haematological and biochemical parameters. Both the doses of extract treated groups of animals showed dose dependent, significant increase in immune response, haematological and biochemical parameters when compared with toxic control group of cyclophosphamide and sheep RBC induced immune suppression. The above observations support the findings that, the extract of Aquilaria malaccensis leaves was able to offer significant protection against cyclophosphamide and sheep RBC induced immune response probably by the presence of array of phytoconstituents and might be beneficial in the treatment of immune suppression related disorders.

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Keywords

Aquilaria malaccensis, Cyclophosphamide, Immunomodulatory effect, Sheep RBC.

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