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Research Journal of Pharmacology and Pharmacodynamics
Year : 2019, Volume : 11, Issue : 1
First page : ( 27) Last page : ( 31)
Print ISSN : 0975-4407. Online ISSN : 2321-5836.
Article DOI : 10.5958/2321-5836.2019.00006.5

Evaluation of Anti-ulcer activity of Ethyl acetate extract of Azima tetracantha Lam in Experimental rats

Jose B. Edwin1, Dr. Muralidharan P.2, Arunmozhivarman P.3,*, Chandrakala B.3, Arunkumar S.3, Arunkumar S. S.3

1Department of Pharmaceutical Chemistry, Sankaralingam Bhuvaneswari College of Pharmacy, Sivakasi

2Department of Pharmacology, C. L. Biad Metha College of Pharmacy, Chennai

3Department of Pharmaceutical Chemistry, SSM College of pharmacy, Erode

*Corresponding Author E-mail: meeraharsa23@gmail.com

Online published on 16 March, 2019.

Abstract

The anti-ulcer activity of ethyl acetate extract of Azima tetracantha Lam (Salvadoraceae) was investigated in pylorus ligation and ethanol induced ulcer models in wistar rats. In both models the common parameter determined was ulcer index. Ethyl acetate extract of Azima tetracantha Lam at doses of 250,500 mg/kg p.o produced significant inhibition of the gastric lesions induced by Pylorus ligation induced ulcer and Ethanol induced gastric ulcer. The extract (250 mg/kg and 500 mg/kg) showed significant (P<0.01) reduction in gastric volume, free acidity and ulcer index as compared to control. This present study indicates that Azima tetracantha Lam extract have potential anti ulcer activity in the both models. These results may further suggest that ethyl acetate extract was found to possess antiulcerogenic as well as ulcer healing properties, which might be due to its antisecretory activity.

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Keywords

Azima tetracantha Lam, Pylorus ligation, Ethanol induced ulcer model, ulcer index.

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