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Research Journal of Pharmacology and Pharmacodynamics
Year : 2018, Volume : 10, Issue : 1
First page : ( 38) Last page : ( 44)
Print ISSN : 0975-4407. Online ISSN : 2321-5836.
Article DOI : 10.5958/2321-5836.2018.00007.1

Structural Architecture and Signal Transduction of Ion Channels: A Review

Sahu Mahendra Kumar*, Satapathy Trilochan, Netam Ashish Kumar, Prasad Jhakeshwar

Department of Pharmacology, Columbia Institute of Pharmacy, Tekari, Near Vidhansabha, Raipur-493111, Dist-Raipur (C.G.) India

*Corresponding Author E-mail: mahendrapharma0310@gmail.com

Online published on 24 May, 2018.


Ions are small charged molecules they have ability to produce signals to exert the pharmacological response. The ions which are mostly carried in physiological conditions are free atoms in solution typically sodium, potassium, calcium and chlorides. Once an ion has permeated or exited the cell, it not only changes its electrical membrane potential, but alsochanges several ions, particularly calcium, is used as messengers within the cell, and can regulate many complicated and long lasting catalytic effects of the cell. Ion channels are made up off glycoprotein (protein with sugar molecules attached) that transverse the cell membrane. They are formed by aggregation of subunits, each a protein by itself, into a cylindrical configuration that allows a pore, thus forming a kind of tube. Ions permeate through their specific channels by electrical potential or differences in concentration gradient across the cell membrane. In this review we have tried to describe the details about the various types of ion channels such as ligand gated ion channels voltage gated channels etc and their signal transduction mechanism for evoke the biological activity.



Ion channel, Ligand gated, Voltage gated, subunits, Response.


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